What about TMG?

TMG is composed of three methyl groups attached to a glycine atom. It can “donate” methyl groups.

TMG is a metabolite of the B vitamin family product called Choline. Choline has 4 methyl groups, TMG has 3 and DMG has 2. These substances plus Folic acid, Vitamin B-12 and SAM-e are all methyl donors. Methyl donors can contribute methyl groups to biological processes such as liver function, detoxification and cellular replication (production of new cells). Methylation protects the kidneys and stimulates production of the fat-transporting molecule l-carnitine.

TMG helps the liver metabolize fats, preventing the accumulation of fats in the liver. It also helps to detoxify chemicals in the liver, while protecting the liver from being damaged by those chemicals.

Methylation with TMG helps to convert the dangerous, inflammatory chemical homocysteine into the amino acid methionine. TMG may lower homocysteine when B-6, B-12 and folic acid cannot.

TMG is also known as Betaine.  TMG may be useful for autistic children, along with B-6 and magnesium. It may also be useful in strengthening the body’s immune response against pathogenic bacteria. There is very preliminary evidence that TMG and methyl donors may help against some forms of seizures.

TMG is 50% more effective than DMG in any application where the methyl groups are useful. Otherwise, they can used interchangeably.  Most Biomedical MDs will start with TMG and if no response or a hyper response, will switch to DMG.

Personally, if I get “hyperactivity” as a side effect of TMG or DMG, I always go back to the GUT!  What am I feeding down there?  Yeast or a bacterial imbalance?  It may be time for a stool culture!

Otherwise, I am looking for increased focus and attention and language as the child makes their own neurotransmitters.  The Detox that occurs in the liver is an added benefit, but one that parents can not “see” right away.

I hope this helps you all to understand TMG and Methylation!

Your Dr. Girlfriend,  Jennifer

PS…let me know if any of you have a supplement that you want to know more about!

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